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B365TT2S01 - ft The growth factor or hormone that plays a...

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Unformatted text preview: ft: The growth factor or hormone that plays a key role in limb. regeneration of amphibians is: 57L 365 @7119: A: transforming growth factor beta“ Dr 7524,; B: epidermal growth factor. " " $91”, at : prolactin $39 0 PMS 'D: insuliniike growth factor I 2: Select the abnormality that is M associated with diabetes mellitus. A: emaciation‘ nreme 1 1 B: polyuria ,...,...,.H_.___,a._._....ms. _Q_m "C: ketonemia -- '- - --——— ' D: metabolic alkalosis 3: The angiogenic factor that shows some structural homology to inhibin and to Mullerian regression factor and that exhibits strong growth-inhibitory activity in most cell types (but not in fibroblasts) is: A: angiogenin B: epidermal growth factor (EGF) «$0: transforming growth factor-beta- D: transforming growth factor—alpha 4: The hormone erythropotetin is released from the kidney in response to hyperoxia. ' A: true 4.. '8: false ,5: The finding that blood calcium levels decreased by about 10% within ' one hour after the perfusion of a high calcium medium (13 mg/100 ml) into a blood vessel of a dog was important because it suggested: A: the existence of parathyroid hormone ----“—?B: the existence of calcitonin C: the product of the plasma concentration of calcium and phosphate is some constant D: calcitonin is a hypercalcemic hormone Page 1. v'l __6: The cleaving oi the alanine side chain of one of the iodinated tyrosines and the joining of the remaining iodinated phenolic ring to the other iodinated tyrosine through the formation of an ether linkage occurs in the: A: secondary lysosomes B: Golgi region C: basal membrane of the follicular cell 4D: follicular lumen near the apical membrane of the follicular cell 7: Lysosomal proteolytic enzymes act within the follicular lumen to release the thyroid hormones from thyroglobulin. 8: if plasma calcium levels in humans fall below 10 rag/100 ml, what hormone is released? A: calcitonin (CT) #497— B: parathyroid hormone (PTH) C: hypocalcin D: glucagon 9: The carboxy—terminal pentapeptide of oholecystokinin is identical to that found in: q7uA: gastrin B: secretin C: glucagon D: gastric inhibitory peptide 10: During the winter when the short—tailed weasel has a white pelage. plasma melanocyte stimulating hormone (MSH) levels would be: a-yfli'A: low B: high G: intermediate D: impossible to say Page 2. v1 ~' 11: Growth hormone has anti-insulin like activity on carbohydrate and fat metabolism because these effects are mediated by somatomedlns. 12: The gastrointestinal hormone that inhibits the release of gastrin from the antral G cells of the stomach is? A: cholecystokinin «zyzB: somatostatln C: secretin D: insulin «13: In the feedback control of “to, 25—dihydroxycholecalciferol biosynthesis, PTH has a stimulatory etfect on: A: conversion of 7-dehydrocholesterol to vitamin D3 B: hepatic 25-hydroxylase Jay-C: kidney 1 alpha—hydroxylase D: all of the above '14: When an animal such as an amphibian is placed in a high albedo environment (bright background), MSH is released from the pituitary. 1.,. 1." A: true -—?')-8: false 15: A patient that has warm, moist palms, rapid pulse, increased body temperature, and who shows signs of nervousness, restlessness. and anxiety would most likely be suffering from: A: cretinism B: hypothyroidism “$0: hyperthyroidism D: a low basal metabolic rate Page 3, v1 16: Select the agent that inhibits active iodide formation and the coupling of iodotyrosyl residues in thyroglobulin. “ail: prOpyIthiouracii — B: perchlorate C: chlorate D: periodate k 17: Estradiol stimulates the release of interleukin—6 by osteoblasts. A: true =1 B: false 18: An etiology of vitaliriguceg _be_t_a__o.ell. destruction is associated with which of the following diseases? 'dfiA: juvenile—onset diabetes mellitus (insulin—dependent diabetes mellitus) B: maturity-onset diabetes mellitus (noninsulin-dependent diabetes mellitus) C: familial hyperproinsulinemia D: diabetes insipidus _19: The sultonylureas such as tolbutamide and carbutamide (so called ”oral insulins") increase insulin release by blocking potassium channels in the beta cells of the islets of Langerhans. *‘5A: True B: False 20: Treatment of a frog with chlorpromazine1 a dogaminergiLracegtor antagonist, would cause the skin to darken because? A: depamine is stimulatory to MSH secretion from the pars intermedia cells -—-}'B: dopamine is inhibitory to MSH secretion from the pars intermedia cells C: acetylcholine is able to depolarize the membranes of the pars intermedia cells D: dopamine is able to depolarize the membranes of the pars intermedia cells Page 4, v1 \ A: True 1’ .578. False “PC-1,5 22' The reiease of enzymes from the sagging Qancreas occurs pnmaniy in response to which of the foilowmg'j hormones?l' r A: secretin " - B: gastrin ~’ C: vasoactive intestine! peptide ' «=7 D choiecystokinrn 23: insulin in its active state has the foliowmg structure a A: A and B chain itnked by two mterchain disuifrde bonds B: A and C chain tinked by two mterchain disuifide bonds 0 A and B chain iinked by three interchain drsuifrde bonds D: an A and B chain linked together by a C chain 24: Meianocyte stimuiat-inigjflh'ormone acts on meianophores and causes the foiiowmg sequence of events to occur A: increased CAMP, relaxation of melanofiiaments B: decreased CAMP, decreased Intracellular contraction of meiancfiia a '0: increased CAMP, decreased intraceiluiar reiaxation of meianofilaments D: increased CAMP, increased intraceiiular " contraction of meianofiiaments increased intraceiiuiar "free" caicium. "free" caiciuml free" calcium, 25: The beta subunits of the insuiin receptor contain the: A: insulin-binding domains ‘8: phosphoiipase C~binding domains Page 5, W C: tyrosine kinase-binding domains D: iipoprotein lipase-binding domains * 26; The source of caicitonin in no_nQammalian yegtebrates is? A: parafollicular C cells of the thyroid —)-B: ultimobranchial glands C: Stannius corpuscles D: chief cell of the parathyroids 27: A marked swelling caused by mucinous protein deposits in the subcutaneous tissues (myxedema) is characteristic of: a ’A: hypothyroidism B: hyperthyroidism C: goiter D: thyrotoxicosis _ 28: The cellular events in glucose—induced insulin secretion by pancreatic beta cells involves glucose transport into the cells by the GLUT2 glucose transporter which in turn results in the opening of potassium channels and the subsequent inhibition of calcium entry into the beta__cell_s. A: True ' " I J; 93: False ,29; Hypoglycemia between meals is prevented primarily by the actions of: A: epinephrine B: insulin —)‘C: glucagon D: ACTH .-301 Extrathyroidal monodeiodination of th triiodothyronine. fiA: true El: false Page 6‘ V1 yroxine is a major source of 31: Insulin release from the beta cells of the islets of Langerhans is inhibited by: A: hyperglycemia B: glucagon at): epinephrine D: arginlne 31% 32: Diabetes mellitus is n_ot associated with which of the following conditions: J- A: excess plasma ketone bodies ,-° 8: hyperglycemia “77-1-0 metabolic alkalosls D: use of fats and proteins as energy substrates 83: Exophthalmos is associated with: A: myxedema fi-B: thyrotoxioosis (excess thyroid hormone action) C: cretinism D: low T3 syndrome 34: The gastrointestinal hormone that in_cha;ses___fllsQlin release in response to glucose is: I .. fins: gastric inhibitory peptide B: gastrin C: cholecystokinin D: secretin 35: Epinephrine and norepinephrine inhibit glucagon release from the alpha cells of the ilets ot Langerhans.K . . I \\ Thar—um! 3‘ \ A: True ,§~ B: False -".;.....36: The gastrointestinal hormone that releases calcitonin in some ' ' species is: ,1?- A: cholecystokinin #3: gastrin C: secretin D: gastric inhibitory peptide Page 7, v1 ‘ 37: Proliferation of smooth muscle cells within the innermost layers of a damaged arterial wall is stimulated by: 'I’A: erythropoietin B: transforming growth factor beta C: epidermal growth factor fl-D: platelet-derived growth factor 38: Identify the condition that is n_ot found in an individual with hyperthyroidism. r-?'A: coarse, dry skin with subdermal thickening B: elevated blood levels of T4 and T3 C: increased appetite D: rapid pulse 39: Insulin increases the release of free fatty acids from chylomicrons in the blood by activating the following enzyme: A: triglyceride lipase a'B: lipoprotein lipase C: cyclooxygenase D: 5-lipoxygenase 40: Destruction of the parathyroid glands would: A: elevate blood calcium levels -3~B: lower blood calcium levels C: cause osteoporosis D: hyperpolarize nerve and muscle membranes 41: Nerve growth factor can affect all of the following except: A: sympathetic ganglia flI—B: somatic motor neurons C: sensory neurons in the dorsal root ganglia D: cholinergic neurons of the basal forebrain Page 8. v1 42: Which of the following relationshi ps relating to the effect of the hormone ieptin on weight control in rats is correct: 9A: smaller fat cells associated with weight release, increased food uptake B: smaller fat cells associated with weight loss release, increased food uptake C: larger fat cells associated with weight release, decreased food intake D: none of the above less, decreased leptin , increased leptin gain, decreased leptin 43: Long~acting thyroid stimulator (LATS) is an antibody that stimulates the TSH receptor and causesa _fgrm____g_t hygartimrgldism. --"'-?'A: true 8: false .- 44: In diabetes meilitus. the amount of gluconeogenesis: «A: decreases ‘58: increases C: remains the same D: does not occur 45: The following enzyme is liq: stimulated by insulin? “7WA: triglyceride lipase B: glucokinase C: glycogen synthetase D: lipoprotein lipase 46: Removal of the thymus gland from an infant results in an impaired immune system because of an absence of B lymphocytes. 47: Vitamin D3 is the prohormone for: A: 7-dehydocholesterol B: ergocalciferot Page 9, v1 0: cholecalciferol 2-,)‘0: lc.25-dihydroxycholecalcifercl 48: Which of the following hormones stimulates gallbladder contraction? a—71A: cholecystokinin (CCK) B: gastric inhibitory peptide (GIP) C: secretin D: gastrin r549: Caloitonin stimulates ostepnlasts to release ac_id phosphatase, \hyalyrqnic acid, and cellagenase. -A: true 98: false 50: The hypoglycemia that would otherwise accompany a meal made up entirely of protein is prevented because amino acids stimulate glucagon as well as insulin release. WA: true B: false Page 10, v1 ...
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