Unformatted text preview: uvrA, B and C ). The protein UvrA recognizes the damage, recruits UvrB and UvrC which cleave at 3' and 5' site of damage, respectively, producing an oligonucleotide of 12 or 13 bases. Helicase necessary to remove oligonucleotide (disruption of hydrogen bonds from base pairing), DNA polymerase fills gap, ligase seals. Nucleotide excision repair also in eukaryotes . Similar mechanism....
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This document was uploaded on 11/03/2011 for the course BIOLOGY MCB2010 at Broward College.
- Fall '10