Assembly and Disassembly

Assembly and Disassembly - hydrolysis of bound ATP to ADP...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
Assembly and Disassembly: Polymerization begins with the formation of small aggregates consisting of 3 actin monomers. ------NUCLEATION Filaments then grow by adding monomers to both ends. The plus end typically grows at a rate 5-10X faster than the minus end. The filament is inherently unstable and can also disassemble from both ends. The monomers bind ATP. ATP is then hydrolyzed to ADP shortly following assembly. The ATP is not required for the polymerization. As with the GTP of tubulin,
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: hydrolysis of bound ATP to ADP reduces the strength of the binding between monomers and decreases the stability of the polymer. Polymerization is reversible [depolymerization occurs when necessary]. The equilibrium between monomers and filaments is dependent upon the concentration of free monomers in the cell. Assembly and disassembly is regulated in part by actin binding proteins...
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online