Assembly and Disassembly

Assembly and Disassembly - hydrolysis of bound ATP to ADP...

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Assembly and Disassembly: Polymerization begins with the formation of small aggregates consisting of 3 actin monomers. ------NUCLEATION Filaments then grow by adding monomers to both ends. The plus end typically grows at a rate 5-10X faster than the minus end. The filament is inherently unstable and can also disassemble from both ends. The monomers bind ATP. ATP is then hydrolyzed to ADP shortly following assembly. The ATP is not required for the polymerization. As with the GTP of tubulin,
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Unformatted text preview: hydrolysis of bound ATP to ADP reduces the strength of the binding between monomers and decreases the stability of the polymer. Polymerization is reversible [depolymerization occurs when necessary]. The equilibrium between monomers and filaments is dependent upon the concentration of free monomers in the cell. Assembly and disassembly is regulated in part by actin binding proteins...
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