EUKARYOTIC TRANSLATION - Recall that there are only 3 known...

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EUKARYOTIC TRANSLATION Eukaryotic primary transcript is processed extensively. Two major differences in prokaryotic mRNA and eukaryotic mRNA are the presence of the 5' CAP and the 3' poly(A)tail. The 5' CAP of 7-methyl guanosine is attached by an unusual 5'-5' linkage to the triphosphate of the first ribonucleotide. See figure As we will soon see, the 5' CAP plays an important role in translation. In initiation : there are at least 10 different eukaryotic initiation factors ( designated eIFs
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Unformatted text preview: ). Recall that there are only 3 known IFs in prokaryotic translation. In elongation : eukaryotic elongation factor eEF-1alpha, eEF-1betagamma, eEF-2 In termination : single eukaryotic release factor eRF second difference from prokaryotes: initiation with unmodified methionine (but also at AUG codon and also with specific initiator tRNA) Greatest difference to prokaryotes: initiation (no Shine-Dalgarno sequence, no initial base pairing between mRNA and rRNA)...
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