EXAMPLE FOR NEGATIVE CONTROL

EXAMPLE FOR NEGATIVE CONTROL - • ß-galactosidase(cleaves...

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EXAMPLE FOR NEGATIVE CONTROL The very first model of gene regulation ever proposed was by François Jacob and Jacques Monod in the 1950s: an important advance in molecular biology. Jacob and Monod analyzed the expression of enzymes involved in lactose metabolism in E. coli . Lactose is the sugar found in milk. E. coli can grow on lactose because it can cleave this disaccharide into its two components glucose and galactose. Enzymes necessary for lactose metabolism
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Unformatted text preview: : • ß-galactosidase (cleaves lactose into glucose and galactose) • lactose permease (transports lactose into the cell) • transacetylase (function unknown) genes that encode the enzymes necessary in lactose metabolism (called structural genes as opposed to regulatory genes): • lac Z (ß-galactosidase) • lac Y (lactose permease) • lac A (transacetylase)...
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