GENETIC RECOMBINATION - differentiation(for example...

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GENETIC RECOMBINATION/REARRANGEMENT Recombination plays an important role in: 1 ) the process of introducing genetic variation by allowing genes to be reassorted into different combinations . For example, genetic recombination results in the exchange of genes between paired homologous chromosomes during meiosis. (Fig. 3.4) 2 ) Also, an important mechanism for repairing damaged DNA (later lecture). 3 ) Recombination also is involved in rearrangements of specific DNA sequences that alter the expression and function of some genes during development and
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Unformatted text preview: differentiation (for example immunoglobulins, the important antibodies of the immune system). DNA molecules recombine by breaking and rejoining . In other words, phosphodiester bonds are broken and rejoined. How can two double-stranded DNA molecules break exactly at the same sites so that no mutations occur? (otherwise there would be a gain of nucleotides for one DNA molecule and loss for the other). Because of Homologous Recombination (recombination between DNA molecules with complementary sequences)...
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