In additio1 - TBP(TATA-binding protein whereas the Inr...

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In addition, there may also be trans-acting regulatory sequences [present far from the actual gene being regulated - even on a separate chromosome]. Genes transcribed by RNA polymerase II have 2 core promoter elements: TATA box Inr sequence The promoter may contain a TATA box or an Inr sequence or both. Recall from lecture on eukaryotic transcription that the TATA box is bound first by
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Unformatted text preview: TBP (TATA-binding protein), whereas the Inr sequence is usually bound first by a TAF (TATA-binding protein associated factors). These two sequences are binding sites for the basal transcription factors. There are other cis-acting regulatory sequences such as the GC box [consensus sequence is GGGCGG]. Specialized transcription factors bind to GC boxes....
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