In Golgi - o Secreted and plasma membrane proteins...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
In Golgi : arrival of vesicles at cis Golgi network , sorting for recycling to ER or further transport to Golgi stack in Golgi stack : further protein processing o via addition of simple oligosaccharides to serines or threonines that lie in a specific sequence context ( O-linked glycosylation , because addition at -OH group of serine or threonine). o Some N-linked oligosaccharides are modified to carry mannose-6- phosphate at their ends ---- targets proteins to lysosome . Specific signal in protein provides information for necessary mannose-6- phosphate modification.
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: o Secreted and plasma membrane proteins extensively modified at their N-linked oligosaccharides when traveling from cisterna to cisterna (but depends on modifying enzymes present in Golgi stack and accessibility of oligosaccharide rather than on a specific signal sequence in the protein) • in trans Golgi network : final sorting! o If no specific signal : in vesicles with bulk flow to plasma membrane . o Specific sequence necessary for retention in Golgi. o Specific sugar signal (mannose-6-phosphate) for lysosome targeting....
View Full Document

{[ snackBarMessage ]}

Ask a homework question - tutors are online