Nuclear Organization - • M Nuclear division(mitosis •...

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Nuclear Organization Nucleus has internal structure that organizes the genetic material and localizes some nuclear functions to discrete sites. The nucleolus is the site at which the rRNA genes are transcribed and ribosomal subunits are assembled. Additional organization suggested by the organization of chromosomes and by the potential localization of functions such as DNA replication and pre-mRNA processing to distinct nuclear domains. Cell Cycle G1 - period between last mitotic division and start of DNA synthesis. Active period of gene transcription. S- DNA is replicated G2- cell further prepares to divide
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Unformatted text preview: • M- Nuclear division (mitosis) • mitosis: prophase, metaphase, anaphase, and telophase • C -Cytoplasmic division (cytokinesis) • During G1 through S, chromatin is dispersed and fills the entire nucleus Makes sense - don't want it to be too condensed for transcription and replication. • Following S and leading up to metaphase of mitosis (100X condensation). • Metaphase chromosomes represent the most condensed phase. • Important because it allows the chromosomes to be faithfully segregated into daughter cells. None of the DNA is transcriptionally active in this conformation....
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