Quaternary Structure - Quaternary Structure The highest...

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Quaternary Structure The highest level of organization, recognized in mutimeric proteins. Aggregates of more than one polypeptide chain. Quaternary structure is the overall 3D structure assumed by the mutimeric protein. The individual polypeptide chains that make up multimeric proteins are often called protein subunits i.e. hemoglobin has 2 each of 2 different subunits Immunoglobulin molecule (IgG) Two types of subunits or polypeptide chains 2 light chains (~25,000 D) 2 heavy chains (~50,000 D) For a given antibody molecule, the two heavy chains are identical to one another in amino acid sequence. The two light chains are identical to one another in amino acid sequence. However, the H and L chains are different in amino acid sequence from every other antibody molecule. Most protein molecules retain their biological activity only within a very limited rnage of temperature and pH. Globular proteins are especially susceptible to these effects. Denaturation is generally observed at Temperatures >60-70C
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Quaternary Structure - Quaternary Structure The highest...

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