Repair mechanisms for gaps

Repair mechanisms for gaps - In error-prone repair the gap...

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Repair mechanisms for gaps: Recombinational repair {SOS repair} Error-prone repair Recombinational repair makes use of the undamaged parental strand to undergo recombination shifting the gap to the other newly synthesized DNA molecule, the one that does not contain the damage (Fig. 5.26). Because the gap is now opposite an undamaged strand, it can be filled by DNA polymerase. And the damage lies now opposite a normal strand and can be dealt with later.
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Unformatted text preview: In error-prone repair , the gap opposite the site of DNA damage is directly filled by newly synthesized DNA. But because of damage to the template the repair is very inacurate and leads to frequent mutations. Error-prone repair is used only in bacteria that have been subjected to potentially lethal conditions (such as extensive UV irradiation), where damage is so enormous that cell death is probably the only alternative....
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