Several major differences in transcription compared to prokaryote1

Several major differences in transcription compared to prokaryote1

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Several major differences in transcription compared to prokaryotes : 1. The process is more complex, partially due to the nucleosomal structure of the DNA. 2. There are 3 different RNA polymerases in the nucleus of eukaryotic cells [termed RNA polymerases I, II, & III] plus an additional mitochondrial RNA polymerase and chloroplast RNA polymerase. 3. All three of the nuclear RNA polymerases do not bind directly to their promoters but to proteins [termed transcription factors ] that are in turn bound to specific DNA sequences that constitute each promoter.
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Unformatted text preview: 4. The mRNAs are longer lived and the processes of transcription and translation are spatially and temporally separated [i.e. transcription occurs in the nucleus, translation occurs in the cytoplasm] 5. The primary transcript must be modified by the addition of a 5'CAP and a poly(A) tail. 6. The mature mRNA is 1/10 the size of the primary transcript due to the removal of introns by RNA splicing. 7. Eukaryotic mRNA is monocistronic...
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This document was uploaded on 11/03/2011 for the course BIOLOGY MCB2010 at Broward College.

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