DNA molecular structure lecture 13

DNA molecular structure lecture 13 - DNA - Molecular...

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Unformatted text preview: DNA - Molecular structure Chapter 10 Characteristics of Genetic Material must contain complex information must replicate faithfully must encode phenotype PROTEIN? NUCLEIC ACIDS? LIPIDS? DNA as genetic material Frederick Griffith 1928 "transformation with Streptococcus pneumoniae Smooth form-virulent Rough form-non-virulent 10.2 p.270 Genetic information Dead virulent Live virulent non 10.3 p.271 DNAase- destroys DNA RNAase- destroys RNA Protease- destroys proteins Ultracentrifugation- eliminates lipids Avery, MacLeod and McCarty (1930s and 1940s) 10.4 p.272 Phage plaques on a lawn of bacteria Alfred Hershey and Martha Chase (1953) 10.5 p.273 Which enters bacteria? Protein or DNA? Primary Structure of DNA Composition Sugar deoxyribose Phosphate Four Nitrogenous bases Purines (double ring) Adenine (A) and Guanine (G) Pyrimidines (single ring) Thymine (T) and Cytosine (C) Sugar phosphate backbone 10.12 p.277 3 5 10.9 p.276 10.10 p.276 Nitrogenous bases 10.12 p.277 3 5 Nucleoside= No Phosphate Nucleo t ide= Has Phosopha t e 10.12 p.277 3 5 Nucleoside= No Phosphate Nucleo t ide= Has Phosopha t e 5 3 http://www.youtube.com/watch?v=saBr4BtbCr0 DNA The Secret of Life- 6 parts on youtube.com Watson-Crick Model building DNA 1953 Structure of Nucleic Acids Phoebus Levene 1910 tetranucleotide hypothesis Suggests each nucleotide would be 1:1:1:1...
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DNA molecular structure lecture 13 - DNA - Molecular...

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