Mendelian Genetics Lecture 4 and 5

Mendelian Genetics Lecture 4 and 5 -...

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Discussion starts this week! Blackboard  HW#1 due this Friday Review Tomorrow (Tues)  HJP 2242 @ 6:00 pm
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Parents Litter
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Parents 1 st generation 2 nd generation
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Hapsburg Jaw
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http://openlearn.open.ac.uk/file.php/3837/S366_1_004i.jpg Achondroplasia fibroblast growth factor receptor gene 3 (FGFR3) – failure of gene to  turn off in development inhibits bone growth,  dominant mutation Seneb 4 th  dynasty Egypt ~2500 BCE
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Albinism in Hopi:  1 in 20,000 1.1 p.2
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Preformationism male sperm carries          all information Or   Female contains    all information 1.11 p.9
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Pangenesis  idea of inheritance of acquired characteristics e.g. Lamarckism 1801  Darwin 1860s   ”gemmules”  Lysenkoism in Russia 1950s 1.10 p.9
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Blending Inheritance- traits are blended each generation
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Mendelian  Mendelian  Genetics Genetics Chapter 3 Chapter 3
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Intrigued by Hybrids http://www.youtube.com/watch?v=b9i-QxW6LhI Paper: Experiments in Plant Hybridization (1865) http://www.mendelweb.org/Mendel.html
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Rosa chinensis -fragrance of tea -color change -small flowers Rosa gigantea -climbing habit -large flowers X Teas-scented  hybrid rose R.  x odorata Crossing between species Hybrids
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Nepenthes ventricosa Nepenthes maxima X Hybrid
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Nepenthes bicalcarata Nepenthes ampullaria Hybrid X
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Brassocattleya   Brassavola nodosa   Cattleya bowringiana   X
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Garden Pea
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Garden Pea – variation within the species
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Visualization of cells 1839 Theodor Schwann - cell theory 1861 Louis Pasteur- disproved spontaneous generation of microbes -germ theory, found yeast ferments wine 1860s State of Biotechnology- Cell Biology 1882- Walther Flemming sees             chromosomes dividing during mitosis
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1838 Jöns Jacob Berzelius- finds proteins -1899 Emil Fischer finds they are strands of amino acids 1858 Friedrich Gaedcke - purifies cocaine from cocoa - used as anesthetic 1889-Richard Altman -finds nucleic acids                - bases found in 1929, structure in 1953   Fractionating cell components 1860s State of Biotechnology- Biochemistry
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Mendels’ Keys to Success  Mendels’ Keys to Success  The garden pea  easy to grow,  selectively cross fertilize or let self-fertilize,  large number of offspring
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Mendel established "pure-breeding" lines for use -creates homozygous plant Mendel used traits with alternative forms (ignored traits  with a range of forms) 3.1 p.48
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Why Mendel? Why Mendel? First to systematically apply the  scientific method to the study of  genetics Observation Hypothesis based on observations Experiments designed to test the  hypothesis Development of explanatory theory Use additional experiments to test and  refine the theory
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Monohybrid crosses Monohybrid crosses crosses between parents that differed in 
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This document was uploaded on 11/04/2011 for the course BSCI 222 at Maryland.

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Mendelian Genetics Lecture 4 and 5 -...

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