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Mendelian Genetics Lecture 4 and 5

Mendelian Genetics Lecture 4 and 5 - Blackboard...

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Discussion starts this week! Blackboard  HW#1 due this Friday Review Tomorrow (Tues)  HJP 2242 @ 6:00 pm
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Parents Litter
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Parents 1 st generation 2 nd generation
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Hapsburg Jaw
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http://openlearn.open.ac.uk/file.php/3837/S366_1_004i.jpg Achondroplasia fibroblast growth factor receptor gene 3 (FGFR3) – failure of gene to  turn off in development inhibits bone growth,  dominant mutation Seneb 4 th  dynasty Egypt ~2500 BCE
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Albinism in Hopi:  1 in 20,000 1.1 p.2
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Preformationism male sperm carries          all information Or   Female contains    all information 1.11 p.9
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Pangenesis  idea of inheritance of acquired characteristics e.g. Lamarckism 1801  Darwin 1860s   ”gemmules”  Lysenkoism in Russia 1950s 1.10 p.9
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Blending Inheritance- traits are blended each generation
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Mendelian  Mendelian  Genetics Genetics Chapter 3 Chapter 3
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Intrigued by Hybrids http://www.youtube.com/watch?v=b9i-QxW6LhI Paper: Experiments in Plant Hybridization (1865) http://www.mendelweb.org/Mendel.html
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Rosa chinensis -fragrance of tea -color change -small flowers Rosa gigantea -climbing habit -large flowers X Teas-scented  hybrid rose R.  x odorata Crossing between species Hybrids
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Nepenthes ventricosa Nepenthes maxima X Hybrid
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Nepenthes bicalcarata Nepenthes ampullaria Hybrid X
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Brassocattleya   Brassavola nodosa   Cattleya bowringiana   X
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Garden Pea
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Garden Pea – variation within the species
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Visualization of cells 1839 Theodor Schwann - cell theory 1861 Louis Pasteur- disproved spontaneous generation of microbes -germ theory, found yeast ferments wine 1860s State of Biotechnology- Cell Biology 1882- Walther Flemming sees             chromosomes dividing during mitosis
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1838 Jöns Jacob Berzelius- finds proteins -1899 Emil Fischer finds they are strands of amino acids 1858 Friedrich Gaedcke - purifies cocaine from cocoa - used as anesthetic 1889-Richard Altman -finds nucleic acids                - bases found in 1929, structure in 1953   Fractionating cell components 1860s State of Biotechnology- Biochemistry
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Mendels’ Keys to Success  Mendels’ Keys to Success  The garden pea  easy to grow,  selectively cross fertilize or let self-fertilize,  large number of offspring
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