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BMB401 F02 T3 - BMB 4011506-— EXAMINATION III NOVEMBER 12...

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Unformatted text preview: BMB 4011506 -— EXAMINATION III NOVEMBER 12. 2002 Dun‘ng the course of this exam you should not be in possession of a beeper or a cellular phone. Please place your beeper or cellular phone in mar book bagfafter you turn it off!!! and place the bag ageing the wall of the room. You can only use calculators that do not have memory capabilities for alphabetic characters. Other calculators should also be placed in your bag. THESE ARE STANDARD SINGLE ANSWER MULTIPLE CHOlCE QUESTIONS. THE POSSIBLE ANSWERS ARE LABELED A, B, C, D, AND E. SELECT THE SINGLE BEST ANSWER AND MARK THE APPROPRIATE CIRCLE ON THE SCANTRON. BUBBLE IN YOUR NAME AND ID# (Cit PLEASE). THERE ARE 5;; QUESTIONS. YOU IlVlLL RECEIVE FULL CREDIT FOR fl CORRECTANSWERS. ' 1. Which one of the following statementsabout citrate is INCORRECT? a. It transports acetyl groups from the mitochondria into the cytosol b. it activates the first enzyme of fatty acid biosynthesis c. it is made in mitochondria by the reaction catalyzed by citrate synthase d. It supplies the C02 required for the formation of malonyl CoA e. It inhibits phosphofructokinase I 2. When excess acetyl CoA. produced by the liver, cannot be utilized by the TCA cycle. it accumulates in the body as: a. Acetyl CoA b. Glucose c. p-hydroxybutyrate d. Glycogen e. Pyruvate 3. Which ONE of the following answers completes the sentence correctly? The major product of the fatty acid synthase complex of mammals is a. Linolenate b. Oleate c. Stearate d. Linoleate e. Palmitate 4. Which one of the following statements about acetyl CoA carboxylase is INCORRECT? a. It is catalyticaliy active when in polymeric state b. it is induced when animals are fed diet rich in carbohydrates c. it is inhibited by palmitoyl CoA d. It is phosphorylated by AMP-activated protein kinase e. It is inactivated by dephosphorylation 5. Which ONE of the following compounds is NOT required for fatty acid synthesis from acetyl CoA? Acetyl CoA Malonyl CoA NADH NADPH ATP cases 6. Which ONE of the following enzymes is activated on phosphorylation catalyzed by cAMP-dependent protein kinase during fasting? Fatty acid synthase HMG-CoA reductase Honnone—sensitive lipase Pancreatic lipase Glycogen synthase 99.0.0!” 7. Which ONE of the following compounds serves as an acceptor for the amino groups of many amino acids during catabolism? a. Oxalate b. Tartaric acid c. a-Ketoglutarate d. Asparagine . e. Glutamine 8. Which of the following answers completes the sentence correctly? The products of an aminotransferase (transaminase)—catalyzed reaction between pyruvate and glutamate would be , Aspartate and glutamate Alanine and u—ketoglutarate Ala nine and oxalo'acetate Aspartate and a-ketoglutarate Asparagine and o-ketoglutarate seeps 9. The synthesis of 3-hydroxy—3-methylglutaryl CoA (HMG-CoA) can occun a. Only in mitochondria of all mammalian cells b. Only in the cytosol of all mammalian cells c. Only in the endoplasmic reticulum of all mammalian cells d. in both the cytosol and mitochondria e. In Iysosomes 10. When the liver is actively synthesizing fatty acids, a concomitant decrease in B-oxidation of fatty acids is due to: a. Inhibition of a iranslocation between cellular compartments b. Inhibition by an end-product c. Activation of an enzyme d. Detergent effects 3. Decreases in adipocyte lipolysis 11. Which of the following compounds is a KEY intermediate in the synthesis of both triacylglycerols and phospholipids? a. GDP—choline b. Triacylglyceride c. Phosphatidylserine d. Phosphatidate .e. CDP—diacylglycerol 12.A 65yearominanhasainfldheanauackand is placed on diet and lovastatin therapy. Which of the following will be a result of this treatment? a. Low blood glucose b. High blood glucose c. Low oxidation of fatty acids d. Low blood cholesterol e. High blood LDLs 13. Which ONE of the following apo—lipoproteins is synthesized by the intestine as part of the coat of chylomicrons? a. B-100 b. 8-48 c. Cii d. E e. A 14. The reactions of the urea cycle occur a. b. c. d. In the nucleus and cytosol in the Iysosome and mitochondria In the mitochondrial matrix and cytosol in peroxisomes and the golgi apparatus e. Only in cytosol 15. Chylomicrons. intermediatemdensity lipoproteins (IDLs), low-density Iipoproieins (LDLs), and very- low—density lipoproteins (VLDLs) are all serum Eipoproteins. What is the correct ordering of these particles from the lowest to the highest density? a. b. c. d. LDLs. IDLs. VLDL, chylomicrons Chylomicrons, VLDLs, lDLs, LDLs VLDLs, IDLs. Chylomicrons. LDLs Chylomicrons, LDLs, VLDLs, IDLs 16. Which ONE of the following co—factors must participate during the conversion of acetyl CoA to malonyl 60A? 3. Thiamine pyrophosphate b. FAD c. NADH d. NADPH e. Biotin 17. Nitrogen of muscle alanine can be derived from tissue ammonia through the action of which ONE of the following enzymes? a. b. C. d. Glutamate dehydrogenase Alanine dehydrogenase Glutamine synthetase Alanine synthetase 18. Which ONE of the following hormones is responsible for secretion of pancreatic zymogens into the intestine? sense Glucagon insulin Cholecystokinin Intrinsic factor Gastnn 19. A compound normally used to conjugate bile acids is: a. b. C. Acetate Propionate Palmitate Glycine Glutathione 20. Aspirin is a pain relieving and anti-inflammatory mediator because it inhibits which ONE of the following enzymes? a. Lipoprotein lipase b. Cyclooxygenase c. Phospholipase D cl. Lipoxygenase 21. Liver cells cannot use ketone bodies for cellular energy production primarily because: a. They lack the form of the fi—ketothiolase necessary to hydrolyze acetoacetyl CoA b. They lack the enzyme hydroxymethylglutaryl CoA (HMG-CoA) lyase 0. They lack the enzyme hydroxymethyglutaryl CoA (HMG—CoA) synthase d. They lack the enzyme acetoacetate succinyI-CoA transferase (CoA transferase) e. They lack the enzyme [3- hydroxybutyrate dehydrogenase 22. Activation of lipoprotein lipase requires which ONE of the following apo—lipoproteins? a. C l b, C ll c. E d. A e. 8—100 23. A deficiency in the ability to secrete enteropeptidase (enterokinase) would lead to ONE of the following conditions after food ingestion? a. Abnormally low levels of intestinal zymogens after food ingestion b. Increased plasma levels of serum amylase c. Abnormally low levels of active intestinal proteases d. None of the above 24. Upregulation of urea cycle activity is attained by: 25. 28. 4 27. 28. 29. a. Altered dietary habits that include increased dietary fat b. Altered dietary habits that include increased carbohydrate c. Elevated cytoplasmic glycine (1. Altered dietary habits that include increased dietary protein Which ONE of the following tissues can metabolize glucose, fatty acids and ketone bodies for ATP production? a. Muscle b. Brain c. Liver d. Adipose tissue e. Red blood cells Most of the reducing equivalents (NADPH) utilized for synthesis of fatty acids can be generated from: a. Glycolysis b. The citric acid cycle c. The pentose phosphate shunt pathway d. Citrate lyase Which of the following answers completes the sentence correctly? Regulation of fatty acid biosynthesis occurs at the enzymatic step catalyzed by: a. Carnitine acyltransferase l b. Acetyl CoA carboxylase c. Pyruvate carboxylase d. Citrate synthase Which ONE of the following phospholipases would you expect to cleave fatty acid present at position 2 of a phospholipid molecule? a. Phospholipase C b. Phospholipase D c. Phospholipase A1 d. Phospholipase A2 Which of the following intermediates in the oxidation of odd-chain fatty acids is likely to appear in the urine in vitamin B12 deficiency? a, Acetic acid b. Pentanoic acid 6. Succinic acid d. Methylrnalonic acid e Acetoacetic acid 30. _Which ONE of the following enzymes is involved in the digestion of ingested protein? a. Chymotrypsinogen b. Trypsinogen C. Pepsin d. Proelastase e. Procarboxypeptidase 31. A compound common to the urea cycle and the TCA cycle is: a. Fumarate b. Lactate c. Pyruvate d. a—Ketoglutarate 32. Which of the following compounds directly provide atoms to form the purine ring? Aspartic acid Gl cine N' formyltetrahydrofolic acid CO; All of the above noose 33. Which of the following answers completes the sentence correctly? The first product of purine nucleotide biosynthesis that contains a complete purine ring (hypoxanthine) is: a. AMP b. GMP c. - XMP (Xanthylate) d. NF 34. Which of the following completes the sentence correctly? Cytidine is a: Purine nucleotide Purine nucleoside Pyrimidine base Pyrimidine nucleoside Pyrimidine nucleotide snows 35. Relative to the well-fed state. fuel utilization after three days of starvation shifts in which of the following ways? ' a. The brain begins to use long chain fatty acids as a fuel b. More glucose is consumed by the brain c. Adipose tissue begins to incorporate fatty acids released from chylomicrons into lipids for storage d. Glycogen is stored as a reserve fuel e. Proteins are degraded in order to provide three-carbon precursors of glucose 36. In adipose tissue, giucose—G-phosphate is NOT converted into which of the following? a. Pyruvate b. Ribose-S—phosphate c. Glycerol-a-phosphate d. Glucose , 37. Which ONE of the following completes the sentence correctly? 5'-Fluorouracil causes irreversible inhibition of thymidylate synthase because it is a a. Competitive inhibitor b. Suicide inhibitor c. Uncompetitive inhibitor d. Non—competitive inhibitor 38. Free fatty acids are transported in plasma: As a component of VLDL As a component of chylomicron remnant As a ligand bound to serum albumin As a component of HDL ' 9.09"!” 39. Why is muscle glycogen not available for‘ maintenance of blood glucose concentration? at. There is insufficient glycogen in muscle for maintenance of blood glucose concentration . . b. Muscle lacks glycogen degradatlve enzymes required for response to blood glucagon c. Moscle lacks glucose-G-phosphatase activity, so it cannot form free glucose d. None of the above 40. Synthesis of 5-phosphoribosyI-1-pyrophosphate (PRPP) is primarily controlled by which ONE of the following nucleotides? a. ATP b. GTP c. CTP d. TTP 41. Which ONE of the following hormones promotes hypoglycemia (decrease in blood glucose concentration)? a. Epinephrine b. Glucagon c. Insulin d. None of the above 42.‘ Which one of the following statements concerning glutamine is INCORRECT? a. Glutamine is responsible for the transport and storage of ammonia in a non-toxic form b. The only fate of glutamine is hydrolysis. to glutamate and ammonia c. ATP is required for the reaction leading to the synthesis of glutamine from glutamate and ammonia d. Giutamine is a substrate in the synthesis of cytosolic carbamoylphosphate e. Glutamine is a substrate in the . synthesis of inosinic acid ...
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