T2.4_Citric_acid_cycle,_electron_transport_and_oxidative

T2.4_Citric_acid_cycle,_electron_transport_and_oxidative -...

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Unformatted text preview: Citric acid cycle, electron transport and oxidative phosphorylation Learning objectives: Know that most fuel molecules enter the cycle as acetyl CoA Understand the biochemical reactions involved in the conversion of pyruvate to acetyl CoA as catalyzed by pyruvate dehdrogenase and to appreciate the mechanism of PDH regulation Know where the TCA cycle is located and why it is considered to be the hub of metabolism Learning objectives, contd. Understand why the cycle works only under aerobic conditions Understand how the cycle oxidizes acetyl CoA to CO 2 and H 2 O Know how the cycle is regulated Understand why plants and certain microorganisms are able to convert acetate into glucose (GLYOXYLATE CYCLE) Learning objectives, contd. Understand that mitochondria contain an electron-transport chain consisting of four complexes of enzymes and electron carriers, designed to extract electrons from NADH (complexes I, III, IV) and FADH 2 (complexes II, III, IV) formed in the TCA cycle and delivered these to oxygen. This results in the formation of water, generating ATP in complex V. Know the several types of electron carrier used in electron transport and that normally the electron transport is tightly coupled to the consumption of oxygen and ATP synthesis. This process is termed, oxidative phosphorylation. Know where the complexes occur in mitochondria, their relation to the inner mitochondrial membrane and how this membrane is important in the process of chemiosmosis, which provides the energy for ATP synthesis. Account for the 36 molecules of ATP that can be formed from 1 molecule of glucose and how this is derived by an understanding of the P:O ratio (moles ATP formed per oxygen atom reduced). TCA cycle (hub of metabolism) and oxidative phosphorylation General concepts: It is the gateway to the aerobic metabolism of any molecule that can be transformed into an acetyl group or a dicarboxylic acid It serves as an important source of precursors for the storage form of fuels (e.g., glycogen, fat) It also provides precursors for the biosynthesis of many other important compounds including amino acids, nucleotide bases, cholesterol and porphyrin TCA cycle and oxidative phosphorylation...
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This document was uploaded on 11/04/2011 for the course BMB 401 at University of Miami.

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T2.4_Citric_acid_cycle,_electron_transport_and_oxidative -...

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