Topic 31, ribosome assembly and RNA pol III

Topic 31, ribosome assembly and RNA pol III - Topic 31:...

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Topic 31: Ribosome assembly, RNA polymerase III transcription, mitochondrial DNA and transcription
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Learning objectives Be able to define the following terms: hnRNA, hnRNP, Be able to describe the general process of ribosomal assembly in eukaryotes, and know locations of assembly Be able to summarize the major characteristics of RNAPIII transcription Distinguish from transcription by RNAPII Be able to describe the major features of mitochondrial DNA and gene expression
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Eukaryotic ribosomal assembly is more complex than prokaryotic Prokaryotic: add purified rRNA and protein subunits to a test tube and ribosomes self- assemble Eukaryotic: “chaperone” proteins required for assembly which are not part of the final product
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Figure 18.19: Proposed pathway for assembly, maturation, and export of 40S and 60S yeast ribosomal subunits. Overview. Conserved building blocks in all eukaryotes, so likely very similar Interesting that one large particle subdivides into 2 smaller particles which then come together later on to make a single larger particle
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RNA abbreviations hnRNA , h eterogeneous n uclear RNA (usually refers to mRNAs) hnRNP , hnRNA with proteins bound to it
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Topic 31, ribosome assembly and RNA pol III - Topic 31:...

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