Topic 32, Protein synthesis

Topic 32, Protein synthesis - Topic 32: Protein synthesis:...

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Topic 32: Protein synthesis: focus on tRNA structure, function, and loading
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Learning objectives Be able to define the following terms: microsomal fraction, tRNA nucleotidyl transferase, aminoacyl tRNA synthetase Be able to explain the 2 main locations of translation and what types of proteins are translated in those locations Be able to describe the structure of a tRNA molecule and the functions of the acceptor stem and the anticodon What is the 3’ terminal sequence of ALL tRNAs? What differs between how that sequence is put in place by eukaryotes and prokaryotes? Be able to define/explain the functions of tRNA nucleotidyl transferase and aminoacyl-tRNA synthetase
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Where does translation take place? There are two main locations: Free ribosomes in the cytoplasm Membrane-associated ribosomes on the rough ER (called rough due to visualization of ribosomes on the membrane) Final destination of protein dictates where mRNA is translated
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Figure 19.01: An electron micrograph of a liver cell showing RER (rough endoplasmic reticulum) and patches of SER (smooth endoplasmic reticulum). Reproduced from The Journal of Cell Biology 56 (1973): 746-761. Copyright 1973, The Rockefeller University Press. Photo courtesy of Don W. Fawcett.
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The microsomal fraction is involved in protein synthesis
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Topic 32, Protein synthesis - Topic 32: Protein synthesis:...

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