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Unformatted text preview: also occur between the V and D regions and the D and J regions of the heavy chain DNA sequence. A third way that diversity can result is through a process of mutation. This process simply involves changes in DNA sequence that occur during differentiation of the B-cell. The figure illustrates how an A:T to G:C transition mutation could change a serine residue into a glycine residue in the resulting immunoglobulin. This process may, in part, explain the diversity observed in hypervariable (CDR) regions....
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- Fall '10