ALLELIC HETEROGENEITY - analysis in 1985 • gene...

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ALLELIC HETEROGENEITY cystic fibrosis (CF): • autosomal recessive disorder affecting 1/2500 newborns in populations of European origin • phenotype: sticky viscous secretions obstruction of pancreas and airways pancreatic insufficiency (treated with enzyme supplements) + lung infections • mapped to chromosome 7 by genetic linkage
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Unformatted text preview: analysis in 1985 • gene identified at molecular level in 1989: encodes a chloride channel protein allelic heterogeneity Would such allelic heterogeneity affect the outcome of combining LOD scores from multiple families with affected children? No, because all such families would show linkage to the same chromosomal locus....
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This note was uploaded on 11/05/2011 for the course BIOLOGY MCB2010 taught by Professor Jessicadigirolamo during the Fall '10 term at Broward College.

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