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Unformatted text preview: but is still strong enough to allow binding. Hence, Ag1 and Ag2 are said to cross-react . Ag3, in contrast, cannot interact very well with anti-Ag1 antibody and would have a K value so low that significant binding would not occur. Ag3, therefore, would not cross-react with Ag1. Would antibody produced in response to Ag2 bind Ag3? Would antibody produced in response to Ag2 bind Ag1? Crossreactivity also forms the basis for several diagnostic tests. For example, infection with Treponema pallidum (syphilis) causes the production of antibodies that cross-react with a substance found in cardiac muscle, cardiolipin. Since it is much easier to obtain pure cardiolipin than pure Treponemal antigens, this cross-reaction is used to test for syphilis (Wassermann test). Likewise, antibodies produced against certain Rickettsia cross-react with antigens from Proteus . Since the latter are much easier to obtain, they can be used to test for the former....
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- Fall '10
- Microbiology, anti-Ag1 antibody