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Unformatted text preview: best APC is, in fact, the B-cell itself. When B-cells bind antigen, the antigen becomes internalized, processed and expressed on the surface of the B-cell. Expression occurs within the class II MHC molecule, which can then be recognized by T-helper cells (CD4 + ). Click the image to animate. Other types of antigen-presenting cells include the macrophage and dendritic cells. These cells either actively phagocytose or pinocytose foreign antigens. The antigens are then processed in a manner similar to that observed for the B-cells. Next, specific antigen epitopes are expressed on the macrophage or dendritic cell surface. Again, this expression occurs within the class II MHC molecule, where T-cell recognition occurs. The stimulated T-cells then release lymphokines that act upon "primed" B-cells (B-cells that have already encountered antigen), inducing B-cell proliferation and differentiation. Click the image to animate....
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- Fall '10
- Microbiology, Major histocompatibility complex, specific antigen, B-cells bind antigen