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DIAGNOSI4 - hygiene • Immunological No vaccines are...

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DIAGNOSIS: Clinical: For the dermatophytes, appearance of the lesions is usually diagnostic. For systemic mycoses, the epidemiology and symptomology are useful clues. Laboratory: Treatment of skin scrapings with 10% potassium hydroxide can reveal hyphae or spores. Most fungi can be grown on Sabouraud's dextrose agar but they are often very difficult to speciate. Some fungi show a yellow fluorescence under 365 nm ultraviolet light. Skin testing for a delayed hypersensitivity response is useful for epidemiologic purposes but often not for diagnosis. CONTROL: Sanitary: Control by sanitary means is difficult, but the incidence of communicable disease can be reduced by good
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Unformatted text preview: hygiene. • Immunological: No vaccines are currently available. • Chemotherapeutic: Many antifungals are available but some are very toxic to the host and must be used with caution. Topical powders and creams often contain tolnaftate or azole derivatives (miconazole, clotrimazole, econazole) and are useful against superficial dermatophytes. Hair or nail disease may be treated with oral griseofulvin, but it is rather toxic. Sporotrichosis may be treated using potassium iodide or amphotericin B (oral). Systemic infections are generally treated by amphotericin B, 5-flourocytosine, miconazole or ketoconazole....
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