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Unformatted text preview: These stages are, of course, initiated upon encounter with antigen and activation by T-cell lymphokines. The activated B-cell first develops into a B-lymphoblast, becoming much larger and shedding all surface immunoglobulin. The B-lymphoblast then develops into a plasma cell, which is, in essence, an antibody factory. This terminal differentiation stage is responsible for production of primarily IgM antibody during the "primary response". Some B-cells, however, do not differentiate into plasma cells. Instead, these cells undergo secondary DNA rearrangements that place the constant region of the IgG, IgA or IgE genes in conjunction with the VDJ genes. This "class switch" establishes the phenotype of these newly differentiated B-cells; these cells remain as long-lived "memory cells". Upon subsequent encounter with antigen, these cells respond very quickly to produce large amounts of IgG, IgA or IgE antibody, generating the "secondary response"....
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This note was uploaded on 11/05/2011 for the course BIOLOGY MCB2010 taught by Professor Jessicadigirolamo during the Fall '10 term at Broward College.
- Fall '10