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DISTINCTIVE PROPERTI11 - rash • Transmission of disease...

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DISTINCTIVE PROPERTIES: Poxviruses are large and brick shaped having a complex symmetry (not icosahedral or helical) and small surface tubules. The genomic DNA has a molecular weight of 100-200 x 10 6 daltons. The virion contains a DNA-dependent RNA polymerase (DDRP, transcription enzyme) that is required for infection. Other enzymes in the virion complete the uncoating process and initiate early replication, which occurs in acidophilic intracytoplasmic inclusions. Poxviruses are antigenically complex but may share common internal antigens. PATHOGENESIS: Smallpox is a systemic infection with a very characteristic
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Unformatted text preview: rash. • Transmission of disease occurs via the respiratory tract. Following a 12 day incubation, lesions first appear in the mouth and throat and then on the skin. The rash develops in a synchronous and centrifugal manner with lesions first taking the macular form, then papular, vesicular, pustular and finally as crusts. • Two forms of smallpox exist: the more serious form, variola major, has about a 50% mortality rate; the less severe form, variola minor results in less than 1% death....
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