DISTINCTIVE PROPERTI12

DISTINCTIVE PROPERTI12 - termed immediate early are...

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DISTINCTIVE PROPERTIES: The morphology of each the Herpesviruses is similar but unique . At the genome level, HSV-1 and HSV-2 share only about 50% DNA homology; the genome molecular weights, however are similar (96 x 10 6 daltons). The genome molecular weights of the other viruses are somewhat larger ; EBV is about 114 x 10 6 ; CMV is about 150 x 10 6 . Except for HSV-1 and HSV-2, the proteins surrounding the genome are immunologically unrelated. Herpes DNA replication involves three coordinately regulated sequential events. Upon entering the host cell, the virus travels to the nucleus. There, a set of genes
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Unformatted text preview: termed immediate early are transcribed by cellular transcription factors to produce a set of proteins, some of which are new transcription factors. This groups of factors recognize viral promoters preceding the early genes. Some of the resultant proteins are replication enzymes while others are a third set of transcription factors that synthesize mRNAs encoding the late genes. The late gene products, then, are structural proteins that encapsidate the newly formed DNA genome to produce new progeny virions....
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