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DISTINCTIVE PROPERTI13 - "high-risk" because they...

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DISTINCTIVE PROPERTIES: Human papillomaviruses (HPVs) produce epithelial tumors of the skin and mucous membranes. More than 100 HPV types have been detected. HPV infections may be latent (asymptomatic), subclinical, or clinical. Most HPV infections are latent; clinical infections are usually apparent as warts . Of the many types of HPV, types 6 and 11 are generally classified as "low risk" because infection with these types has a low potential for producing cancerous lesions. These two types of HPv are thought to be responsible for 90% of all genital warts cases. On the other hand, HPV types 16 and 18 are classified as
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Unformatted text preview: "high-risk" because they are responsible for most of the lesions that may progress to cancers, particularly those in the anogenital and/or mucosal category. These two types are thought to be responsible for 70% of cervical cancer cases. • In "low risk" infections, the HPV genome is thought to exist as a separate circular dsDNA molecule, while in "high risk" malignant infections, the genome is incorporated into the host genome. Some of the viral proteins inactivate host cell tumor suppressor proteins, and this may lead to carcinomas....
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