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DISTINCTIVE PROPERTI15 - • The very lipid nature of the...

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DISTINCTIVE PROPERTIES: Mycobacteria are considered "acid-fast", which means that they retain dyes following an acid-alcohol decolorization step. These organisms are very slow growers; a 5 hour division time is not uncommon. Different species can be differentiated based on growth rate, niacin secretion, reduction of nitrate, caratogenesis, etc. Mycobacteria produce "cord factors", which are dimycolates of trehalose. This gives rise to a pattern of growth in serpentine cords.
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Unformatted text preview: • The very lipid nature of the cell wall provides some resistance to drying, acid or alkaline conditions. It is also a good adjuvant that enhances humoral and cell-mediated immune responses. The responsible component may be N-acetyl-muramyl-L-alanyl-D-isoglutamine (MDP), which causes the inhibition of macrophage migration. • M. leprae has never been cultured in vitro but can be grown on the footpads of armadillos....
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