DISTINCTIVE PROPERTI18 - kidneys. Multiplication in the...

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DISTINCTIVE PROPERTIES: Leptospira are thin, tightly coiled obligate aerobes that are highly motile. Their structure is similar to other spirochetes; a multilayered outer membrane, helical shaped peptidoglycan and flagella located in the periplasmic space. Their nutritional requirements include long-chain fatty acids and vitamins B1 and B12. There are more than 180 serotypes of Leptospira described. PATHOGENESIS: Mucosa and broken skin provide the entry for leptospires. The organisms produce a generalized infection with bacteremia (leptospiremic phase). Antibody is produced and the organisms then become localized primarily in the
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Unformatted text preview: kidneys. Multiplication in the kidneys leads to shedding in the urine (leptospiruric phase). This may persist for weeks, months or years. Leptospira produce no known exo- or endotoxins. Damage to the endothelial lining of capillaries and renal failure are the most common reasons for death. Occasionally the central nervous system may become involved. The host immune response is probably responsible for lesions associated with late phase of disease. This is suggested because antibiotics are ineffective after symptoms have persisted for more than 4 days...
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This note was uploaded on 11/05/2011 for the course BIOLOGY MCB2010 taught by Professor Jessicadigirolamo during the Fall '10 term at Broward College.

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