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Unformatted text preview: produce cytotoxic substances that damage ciliated epithelial cells in fallopian tubes; the LPS endotoxin may be partly responsible. • N. gonorrhoeae also produce an extracellular protease that cleaves a proline-threonine bond in immunoglobulin IgA. This causes loss of antibody activity. • Approximately 9-15% of affected women contract Pelvic Inflammatory Disease (PID) as a consequence of gonorrhea. This is often a polymicrobic infection involving Bacteroides and other anaerobes. • The virulence of N. meningitidis is associated with its antiphagocytic capsule. • The meningococcal LPS is as toxic as Escherichia or Salmonella and causes suppression of leukotriene B4 (a chemokinetic/chemotactic factor) synthesis in PMNs. • Untreated, meningococcal meningitis has a mortality approaching 85%. • N. meningitidis produces proline-threonine and proline-serine proteases, but any particular isolate will only produce one or the other....
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- Fall '10
- Microbiology, Pelvic inflammatory disease, Neisseria gonorrhoeae, Neisseria meningitidis, N. meningitidis