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Unformatted text preview: produce cytotoxic substances that damage ciliated epithelial cells in fallopian tubes; the LPS endotoxin may be partly responsible. N. gonorrhoeae also produce an extracellular protease that cleaves a proline-threonine bond in immunoglobulin IgA. This causes loss of antibody activity. Approximately 9-15% of affected women contract Pelvic Inflammatory Disease (PID) as a consequence of gonorrhea. This is often a polymicrobic infection involving Bacteroides and other anaerobes. The virulence of N. meningitidis is associated with its antiphagocytic capsule. The meningococcal LPS is as toxic as Escherichia or Salmonella and causes suppression of leukotriene B4 (a chemokinetic/chemotactic factor) synthesis in PMNs. Untreated, meningococcal meningitis has a mortality approaching 85%. N. meningitidis produces proline-threonine and proline-serine proteases, but any particular isolate will only produce one or the other....
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- Fall '10