DISTINCTIVE PROPERTI23 - localized abscess, which is...

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DISTINCTIVE PROPERTIES: The genus Brucella is composed of Gram negative coccobacilli. Most are aerobic but grow best in a 5-10% CO 2 -enriched environment. Their metabolism is oxidative. Brucellae possess a typical Gram-negative LPS endotoxin, as well as two major serological determinants; A and M. PATHOGENESIS: Of the four species that cause disease in humans, B. melitensis and B. suis are more transmissible to humans, particularly via the oral route. These bacteria are intracellular parasites of the reticuloendothelial (RE) system (e.g. spleen, liver, bone marrow, lymph nodes and kidneys). Following exposure, the organisms may produce a
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Unformatted text preview: localized abscess, which is followed by bacteremia. Phagocytosis by macrophages and intracellular multiplication leads to localization in the RE tissues. Disease may remain subacute or become chronic with initial symptoms of malaise, chills, weakness and intermittent fever. Granulomas in various RE tissues may occur as a result of a hypersensitivity reaction. In animals, multiplication occurs in the uterus because of the presence of erythritol, which the bacteria prefer to glucose . This localization can lead to abortion or excretion in milk (human source for infection)....
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