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DISTINCTIVE PROPERTI25 - bacterial pneumonia types 8 9 10...

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DISTINCTIVE PROPERTIES: These bacteria are all facultative Gram negative bacilli. Except for Proteus , they all ferment lactose. Except for Klebsiella , they are all motile. Each genus has a typical Gram- negative cell wall containing LPS. Antigens possessed by these organisms include the H (flagellar), K (capsular) and O (somatic). Those organisms that possess fimbriae (common pili) use these appendages for adhesion purposes. All genera produce the characteristic LPS endotoxin and some genera/species produce exotoxins. PATHOGENESIS: Generally, these organisms are opportunistic pathogens. E. coli is perhaps the best studied. The site of infection may be specific for a particular serotype. For example, Klebsiella capsular types 1 and 2 are most commonly associated with the production of
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Unformatted text preview: bacterial pneumonia; types 8, 9, 10 and 24 are more commonly associated with urinary tract infections. This finding suggests that these antigenic specificities may provide a site-specific pathogenicity to the organisms. In support of this idea, E. coli displaying the K1 antigen have a propensity for producing neonatal meningitis. The K1 antigen provides the organism with an increased resistance to phagocytosis and the action of complement. The fact that this K1 antigen is cross reactive with the capsular antigen from group B meningococci (also capable of producing meningitis) suggests that the specific antigenic makeup of a particular organism may help to determine the sites where it can produce infections....
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