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DISTINCTIVE PROPERTIE2 - • C botulinum produces oval...

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DISTINCTIVE PROPERTIES: Clostridium species are Gram-positive, rod-shaped, spore- formers. These generally obligate anaerobes are ubiquitous saprophytes or part of our normal flora. Clostridia employ butyric fermentation pathways to generate energy and, as a result, often produce a foul odor. C. perfringens produces large rectangular spores and is non-motile. This species is most often associated with wound infections but these are generally polymicrobic. C. tetani produces terminal spores, giving it the appearance of a squash racket. This species is motile and produces a single antigenic type of exotoxin.
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Unformatted text preview: • C. botulinum produces oval subterminal spores and is motile. Different strains within this species produce one of 8 exotoxin types (A,B,C1,C2,D,E,F,G). Types C and D are encoded by bacteriophage that infect the bacteria. • C. difficile produces large oval subterminal spores and two different toxins; toxin A (an enterotoxin causing fluid accumulation in the intestine) and toxin B (a cytopathic agent). Ordinarily, this species can't compete with normal intestinal flora but, when antibiotics eliminate these normal flora, C. difficile can flourish, producing disease....
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