DISTINCTIVE PROPERTIE6 - central nervous system(CNS tissue...

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DISTINCTIVE PROPERTIES: Rhabdoviruses possess a lipid envelope displaying a surface glycoprotein. The RNA-binding nucleocapsid protein surrounds the RNA genome. The virion itself contains an RNA-dependent RNA polymerase (RDRP). During replication, the virus first makes short positive strand RNAs (mRNAs) which are translated to produce proteins. Later , a full length positive RNA is transcribed and this is used to produce the full length negative strand RNA that is packaged into progeny. PATHOGENESIS: Rhabdoviruses generally enter via a bite or a wound infected with saliva. Initially, the virus replicates at the site and then infects
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Unformatted text preview: central nervous system (CNS) tissue. Following a variable (6 days up to 1 year, average 30-70 days) incubation period, the virus spreads rapidly via the nerves. CNS damage produces the symptoms of disease. • Neurons accumulate ribonucleoprotein as intracytoplasmic inclusions (Negri bodies). Infection of the thalamus, hypothalamus or pons may occur. • Symptoms include fever, excitation, dilation of the pupils, excessive lacrimation, salivation, anxiety, hydrophobia due to spasms of the throat muscles and, eventually, death....
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