DISTINCTIVE PROPERTIE6

DISTINCTIVE PROPERTIE6 - central nervous system (CNS)...

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DISTINCTIVE PROPERTIES: Rhabdoviruses possess a lipid envelope displaying a surface glycoprotein. The RNA-binding nucleocapsid protein surrounds the RNA genome. The virion itself contains an RNA-dependent RNA polymerase (RDRP). During replication, the virus first makes short positive strand RNAs (mRNAs) which are translated to produce proteins. Later , a full length positive RNA is transcribed and this is used to produce the full length negative strand RNA that is packaged into progeny. PATHOGENESIS: Rhabdoviruses generally enter via a bite or a wound infected with saliva. Initially, the virus replicates at the site and then infects
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Unformatted text preview: central nervous system (CNS) tissue. Following a variable (6 days up to 1 year, average 30-70 days) incubation period, the virus spreads rapidly via the nerves. CNS damage produces the symptoms of disease. Neurons accumulate ribonucleoprotein as intracytoplasmic inclusions (Negri bodies). Infection of the thalamus, hypothalamus or pons may occur. Symptoms include fever, excitation, dilation of the pupils, excessive lacrimation, salivation, anxiety, hydrophobia due to spasms of the throat muscles and, eventually, death....
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