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Unformatted text preview: -9 p (affected because of random mating) = 10-8 Thus, ~ 1 /3 of affected individuals will come from 1 st cousin marriages Note that this proportion depends on allele frequency such that traits caused by very rare alleles will more often be the result of consanguinity For rare diseases, it is often quite difficult to tell whether or not they are of genetic origin. A useful method to identify disorders that are likely to be inherited is to ask whether an unusually high proportion of affected individuals have parents that are related to one another....
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- Fall '10