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Unformatted text preview: and tissues. Phagocytosis is somewhat variable. After infection, factors such as fever (viral replication is strongly influenced by temperature) and inflammatory processes including edema, leukocyte accumulation, local hyperthermia, reduced oxygen tension and altered cell metabolism can all act to reduce viral replication. Another important anti-viral factor is interferon. This substance is produced by an infected cell. It then reacts with other cells to i) activate an RNA endonuclease causing mRNA degradation or ii) cause phosphorylation of eIF2, essentially turning off cellular protein synthesis. Specific host defenses include antiviral antibody, which may prevent adsorption to target cells and cytotoxic T-lymphocytes, which recognize virally-infected cells and destroy them, reducing viral production....
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