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Herpesviruses - capable of latency This can lead to...

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Herpesviruses VIRUS: Herpesviruses: Herpes Simplex (HSV-1, HSV-2), Varicella- Zoster virus (VZV), Cytomegalovirus (CMV), Epstein-Barr virus (EBV) GENERAL CONCEPTS: The Herpesviruses are a large group containing more than 70 members that infect organisms from fungi to humans. The Herpesviruses contain a linear DNA genome and are enveloped (bilayered with surface projections derived from the host cell nuclear membrane). Replication occurs in the host cell nucleus. Herpesviruses cause acute infections but they are also
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Unformatted text preview: capable of latency. This can lead to recurrent infections, which are important to the mechanism of host to host transmission. HSV-1, HSV-2 and VZV are termed "neurotropic" while CMV and EBV are "lymphotropic", referring to the cell type in which the latent infection is established. • Some Herpesviruses have been associated with the production of cancers, providing the best evidence for a viral etiology for these diseases. • Humans are the natural host for HSV, VZV, CMV and EBV....
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