HOST DEFENS18 - Humans acquire disease via ingestion of...

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HOST DEFENSES: Antibodies specific for the F1 and VW antigens are opsonic and confer immunity by enhancing phagocytosis and intracellular killing by PMNs. EPIDEMIOLOGY: Plague occurs in urban or wild rodent populations: humans acquire disease primarily via infected fleas. The Yersinia multiply in the flea intestinal tract. Upon biting a new host, the flea regurgitates, inoculating the new host with the organisms. Y. enterocolitica is an intestinal parasite of animals.
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Unformatted text preview: Humans acquire disease via ingestion of contaminated food or water. DIAGNOSIS: • Clinical: Rapid diagnosis must be made because of the speed at which the disease progresses and the high mortality rate. Bubonic plague can result in 75% mortality with a few days; the pneumonic form can result in greater than 90% mortality within 24 hours. Diagnosis of Yersinia gastroenteritis requires laboratory confirmation ....
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