HOST DEFENSE1 - of the normal human flora • Heroin...

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HOST DEFENSES: Gas gangrene: Host defenses are ineffective. Tetanus: No innate immunity. Disease episodes are ineffective (too little toxin released). Botulism: Toxin is poorly absorbed in intestine. Disease episodes are ineffective (too little toxin released). Pseudomembranous colitis: Normal flora play an important role. Other host defenses are unknown. EPIDEMIOLOGY: The clostridia are ubiquitous in the soil and some are part
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Unformatted text preview: of the normal human flora. • Heroin addicts are particularly susceptible to tetanus as a consequence of their life style. • Poorly canned foods create an anaerobic environment. Unkilled spores germinate and produce toxin. • PC patients secrete large numbers of spores in feces. This provides a reservoir....
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