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HOST DEFENSE7 - rubella syndrome DIAGNOSIS • Clinical...

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HOST DEFENSES: Humoral defenses soon after the viremia help to clear the virus from the blood and prevent continued spread. Cell- mediated defenses clear the virus from tissues. The immune responses generated by natural infections provide life-long immunity. EPIDEMIOLOGY: Before the vaccine, sporadic outbreaks and epidemics occurred every 6-9 years following a seasonal pattern (late winter, early spring, typical for respiratory disease). An epidemic in 1964-65 in the US produced 12.5 million cases of disease and resulted in 20,000 cases of congenital
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Unformatted text preview: rubella syndrome. DIAGNOSIS: • Clinical: Following a 14-20 day incubation period (the "prodrome"), a rash develops on the face and neck and then the trunk and extremities. Lymph nodes become enlarged about a week before the rash and persist for 1-2 weeks after. Congenital rubella symptoms vary depending on the organs affected but typically the eyes, ears, heart and brain are involved. Confirmation of disease is critical in pregnant women. • Laboratory: Illustrating a 4-fold increase in serum titer against Rubellavirus is diagnostic....
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