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Unformatted text preview: itself, a LOD score of 3. Approach 2: Direct search for mutations in candidate genes. In some diseases, one can make good guesses as to the biochemical structures or pathways that are likely sites of causative mutations. In such cases, a direct search for mutations at the DNA sequence level in "candidate genes" -- can be an effective strategy -- even in the absence of any prior genetic linkage analysis....
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- Fall '10