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Unformatted text preview: amino acids. Each chain has "constant" and "variable" regions as shown in the figure. Variable regions are contained within the amino (NH 2 ) terminal end of the polypeptide chain (amino acids 1-110). When comparing one antibody to another, these amino acid sequences are quite distinct. Constant regions, comprising amino acids 111-220 (or 440-550), are rather uniform, in comparison, from one antibody to another, within the same isotype. "Hypervariable" regions, or "Complementarity Determining Regions" (CDRs) are found within the variable regions of both the heavy and light chains. These regions serve to recognize and bind specifically to antigen. The four polypeptide chains are held together by covalent disulfide (-S-S-) bonds....
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- Fall '10