Measles - body Complications are mainly bacterial...

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Measles: Measles is also a systemic infection spread by viremia. Acute disease affects the lymphatic and respiratory systems and occasionally the brain. Persistence of the virus can produce SSPE. Measles virus generally enters via the oropharynx. Local multiplication precedes the viremia and spread to the reticuloendothelial system. Extensive multiplication produces a secondary viremia 5-7 days later with spread to the mucosa of the respiratory, urogenital or gastrointestinal tracts or the central nervous system. Clinically, there are respiratory symptoms during the prodromal stage (malaise, fever, cough) and a rash during the eruptive phase (Koplik's spots, rash on head then
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Unformatted text preview: body). Complications are mainly bacterial superinfection but other rare complications (e.g. SSPE) can occur. • RSV: The RS virus initiates a local infection in the upper or lower respiratory tract but illness varies with age and previous experience. The virus infects ciliated epithelia of the nose, eye and mouth and remains generally confined. Virus spreads extracellularly and by fusion. Severe disease may present as bronchiolitis, pneumonia or croup, particularly in infants. Some evidence suggests that there are possible immunopathologic mechanisms involved....
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