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Unformatted text preview: (u); backward mutation changes a to A at a rate (v). We can express the frequency (p) of the A allele in the next generation (p t+1 ) in terms of these opposing forward and reverse mutations, much like forward and reverse chemical equations: (p t+1 ) = p t (1u) + q t (v). The first part on the right is accounts for alleles not mutated (1u), and the second part accounts for the increase in p due to mutation from a to A (the frequency of a times the mutation rate to A). We can also describe the change in allele frequency between generations ( p) as: p = (p t+1 )  (p t ) . This is useful because it lets us calculate a theoretical equilibrium frequency which is defined as the point at which there is no more change in allele frequencies, i.e. when p = 0 which is when (p t+1 ) = (p t ) ; from above: p t (1u) + (1p) t (v) = p t [remember, q=(1p)]. Now solve for p and convince yourself that the equilibrium frequency = p = v/(u+v) . Similarly the equilibrium frequency of q = u/(u+v)....
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This note was uploaded on 11/05/2011 for the course BIOLOGY MCB2010 taught by Professor Jessicadigirolamo during the Fall '10 term at Broward College.
 Fall '10
 JessicaDigirolamo
 Microbiology, Mutation

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