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Unformatted text preview: that are 1 st cousins. As we have already calculated, the probability that a grandparental allele will become homozygous is 1 /64 for 1 st cousins Thus, each recessive lethal allele for which one of the grandparents in a carrier will contribute an increased probability of 0.016 that the grandchild will be homozygous and therefore be afflicted by a lethal inherited defect. To look for this effect we will use the frequency of stillbirth or neonatal death from 1 st cousin marriages. We must also be careful to subtract the background frequency of stillbirths and neonatal deaths that are not due to genetic factors. These frequencies can be obtained from the cases where parents are not related...
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 Fall '10
 JessicaDigirolamo
 Microbiology, Mutation

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