One prediction of the neutral theory is that

One prediction of the neutral theory is that - One...

Info iconThis preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
One prediction of the neutral theory is that silent (synonymous) sites in protein coding regions will evolve faster than replacement (nonsynonymous) sites (due to different functional constraints). This provides a null hypothesis about DNA evolution. Most sequences fit this neutral model; however, the histocompatibility loci appear to deviate from a neutral model in that there are more nonsynonymous substitutions than synonymous substitutions. This holds only for the antigen binding region; the rest of the molecule is consistent with neutral expectations. (see figure 7.10, pg. 185). Another prediction of the neutral theory is that amount of sequence divergence will be correlated with the level of heterozygosity ; heterozygosity is measured as 2pq for a two allele situation or (2pq+2pr+2qr) for a three allele situation, or 1- x i 2 for i alleles; see figure 5.2 pg. 96 for a two allele view). Loci with high heterozygosity should evolve at a faster rate under the assumption that these loci have a higher rate of
Background image of page 1
This is the end of the preview. Sign up to access the rest of the document.

This note was uploaded on 11/05/2011 for the course BIOLOGY MCB2010 taught by Professor Jessicadigirolamo during the Fall '10 term at Broward College.

Ask a homework question - tutors are online