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Papillomaviruses - • Human papillomaviruses are trophic...

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Papillomaviruses VIRUS: Human Papilloma Virus (HPV) GENERAL CONCEPTS: The Papillomaviruses are small, non-enveloped icosahedral particles containing a circular dsDNA genome. Papillomaviruses are a member of the Papovavirus family, which is divided into 2 genera: o Polyomavirus , which contains a 5200 base pair DNA genome and has been employed as a good molecular model system. There are 2 polyoma viruses that cause disease in humans; BKV and JCV. o Papillomavirus , which contains an 8000 base pair DNA genome, can induce benign tumors of the head and neck, several varieties of skin warts, and cervical cancers.
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Unformatted text preview: • Human papillomaviruses are trophic for epithelial cells of the skin and mucus membranes. They appear to replicate in the cell nucleus and have two modes of replication: o Stable replication in basal cells and o Vegetative replication in more differentiated cells that generates progeny virions. • Human papillomavirus (HPV) is thought to be the most common sexually transmitted disease in the world. • The CDC estimates that there are approximately 6.2 million new cases of sexually transmitted HPV infections annually and that over 20 million people are already infected....
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