Papillomaviruses - Human papillomaviruses are trophic for...

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Papillomaviruses VIRUS: Human Papilloma Virus (HPV) GENERAL CONCEPTS: The Papillomaviruses are small, non-enveloped icosahedral particles containing a circular dsDNA genome. Papillomaviruses are a member of the Papovavirus family, which is divided into 2 genera: o Polyomavirus , which contains a 5200 base pair DNA genome and has been employed as a good molecular model system. There are 2 polyoma viruses that cause disease in humans; BKV and JCV. o Papillomavirus , which contains an 8000 base pair DNA genome, can induce benign tumors of the head and neck, several varieties of skin warts, and cervical cancers.
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Unformatted text preview: Human papillomaviruses are trophic for epithelial cells of the skin and mucus membranes. They appear to replicate in the cell nucleus and have two modes of replication: o Stable replication in basal cells and o Vegetative replication in more differentiated cells that generates progeny virions. Human papillomavirus (HPV) is thought to be the most common sexually transmitted disease in the world. The CDC estimates that there are approximately 6.2 million new cases of sexually transmitted HPV infections annually and that over 20 million people are already infected....
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