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Paramyxoviruses - within the virus particle •...

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Paramyxoviruses VIRUS: Paramyxoviruses: Parainfluenza, Mumps, Measles, Respiratory Syncytial Virus GENERAL CONCEPTS: The Paramyxoviruses are an important cause of respiratory disease in children. Illnesses include croup, bronchiolitis and pneumonitis. This group of viruses share similar features; they possess a double layered envelope with spikes, have a helical symmetry and contain a negative stranded RNA genome. An RNA-dependent RNA polymerase (RDRP) is contained
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Unformatted text preview: within the virus particle. • Paramyxoviruses replicate in the cytoplasm and are released by budding. • Virus-specific antigens include those associated with the envelope and those contained within the nucleocapsid. • The host range for the Paramyxoviruses includes humans and monkeys. • These viruses produce multinucleated giant cells (syncytia) by production of a cell fusing factor, and then cause host cell lysis....
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