PATHOGENES10 - which are fungal metabolites that are toxic...

Info icon This preview shows page 1. Sign up to view the full content.

View Full Document Right Arrow Icon
PATHOGENESIS: Mycotic disease is often a consequence of predisposing factors including age, stress or other pathologic conditions (e.g. cancer, diabetes, AIDS). Only the dermatophytes ( Trichophyton , Microsporum ) and Candida are communicable from human to human. The other agents are acquired from the environment (plants, soil, etc.). Fungi generally cause one of three distinct tissue responses; 1. chronic inflammation (scarring, accumulation of lymphocytes) 2. granulomatous inflammation (collections of modified epithelial cells, lymphocytes) 3. acute suppurative inflammation (vascular congestion, exudation of plasma, accumulation of PMNs). Some of the tissue responses may be due to mycotoxins,
Image of page 1
This is the end of the preview. Sign up to access the rest of the document.

Unformatted text preview: which are fungal metabolites that are toxic to the host. Some agents produce LPS-like endotoxins or hemolysins or steroid-like toxins that affect the nervous system • Aspergillus produces a toxin called aflatoxin that has a strong association with liver cancer. For example, in Thailand, where people generally consume about 25-times more aflatoxin in their diets, the incidence of cancer is about 10-fold greater. • Systemic mycoses are generally asymptomatic but may have generalized symptoms including low grade fever, shaking chills, night sweats, malaise or appetite loss....
View Full Document

{[ snackBarMessage ]}

What students are saying

  • Left Quote Icon

    As a current student on this bumpy collegiate pathway, I stumbled upon Course Hero, where I can find study resources for nearly all my courses, get online help from tutors 24/7, and even share my old projects, papers, and lecture notes with other students.

    Student Picture

    Kiran Temple University Fox School of Business ‘17, Course Hero Intern

  • Left Quote Icon

    I cannot even describe how much Course Hero helped me this summer. It’s truly become something I can always rely on and help me. In the end, I was not only able to survive summer classes, but I was able to thrive thanks to Course Hero.

    Student Picture

    Dana University of Pennsylvania ‘17, Course Hero Intern

  • Left Quote Icon

    The ability to access any university’s resources through Course Hero proved invaluable in my case. I was behind on Tulane coursework and actually used UCLA’s materials to help me move forward and get everything together on time.

    Student Picture

    Jill Tulane University ‘16, Course Hero Intern