PATHOGENES10 - which are fungal metabolites that are toxic...

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PATHOGENESIS: Mycotic disease is often a consequence of predisposing factors including age, stress or other pathologic conditions (e.g. cancer, diabetes, AIDS). Only the dermatophytes ( Trichophyton , Microsporum ) and Candida are communicable from human to human. The other agents are acquired from the environment (plants, soil, etc.). Fungi generally cause one of three distinct tissue responses; 1. chronic inflammation (scarring, accumulation of lymphocytes) 2. granulomatous inflammation (collections of modified epithelial cells, lymphocytes) 3. acute suppurative inflammation (vascular congestion, exudation of plasma, accumulation of PMNs). Some of the tissue responses may be due to mycotoxins,
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Unformatted text preview: which are fungal metabolites that are toxic to the host. Some agents produce LPS-like endotoxins or hemolysins or steroid-like toxins that affect the nervous system • Aspergillus produces a toxin called aflatoxin that has a strong association with liver cancer. For example, in Thailand, where people generally consume about 25-times more aflatoxin in their diets, the incidence of cancer is about 10-fold greater. • Systemic mycoses are generally asymptomatic but may have generalized symptoms including low grade fever, shaking chills, night sweats, malaise or appetite loss....
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This note was uploaded on 11/05/2011 for the course BIOLOGY MCB2010 taught by Professor Jessicadigirolamo during the Fall '10 term at Broward College.

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