PATHOGENES11 - two forms tuberculoid or lepromatous HOST...

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PATHOGENESIS: M. tuberculosis is the agent responsible for the disease tuberculosis. Virulent strains of Mycobacteria have the capacity to disrupt phagosomal membranes of alveolar macrophages while the cord factors inactivate mitochondrial membranes of phagocytes. These properties enable the organisms to survive and multiply in phagocytes. Leprosy is caused by M. leprae and may appear in one of
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Unformatted text preview: two forms; tuberculoid or lepromatous. HOST DEFENSES: • It is the cell-mediated immune response (delayed hypersensitivity) that leads to the production of the granulomatous lesion known as a tubercle. This lesion contains a core of rounded macrophages, surrounded by outer giant cells. Persistence of the lesion gives rise to a cheesy caseation necrosis and, eventually, calcification....
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